ABSTRACT
<p><b>OBJECTIVE</b>To establish, a novel method, Dual index information markedly similar sequence clustering analysis to identify and control the quality of formula Chinese patent medicine.</p><p><b>METHOD</b>Based on common and variation peak ratio dual index sequence analysis proposed by authors, a new equation was built up, in which the common inherited and variant information could be integrated into unique information represent. It described the properties of biological samples simply and synthetically. The dual index information markedly similar sequence were determined and used to cluster samples.</p><p><b>RESULT</b>The novel approach was applied for pattern recognition of IR fingerprint spectra of components of Guifu dihuang and Jingui shenqi pills, composed of extremely similar components extracted with ethanol, the two pills could be classified accurately and distinctly.</p><p><b>CONCLUSION</b>The dual index information markedly similar sequence clustering method is an excellent one-fit pattern recognition one fit to analyze biologically complex samples.</p>
Subject(s)
Drugs, Chinese Herbal , Chemistry , Ethanol , Chemistry , Medical Informatics , Methods , Medicine, Chinese Traditional , Reference Standards , Quality Control , Spectrophotometry, InfraredABSTRACT
AIM: To set up a new method to analyze IR fingerprint spectra, which was in line with the cha racteristic of traditional Chinese medicine. METHODS: In this paper. two new indexes, common peak ratio and variant peak ratio, were applied and its values were calculated by means of the sequential analysis, in which each sample's IR fingerprint spectra was set up and the common peak ratio sequences were arranged in order of size in comparison with other samples. RESULTS: The method could distinguish the water extract of Radix Glycyrrhizae of different varieties and different areas. CONCLUSION: The dual index sequential analysis enables us to distinct two or more herb's IR fingerprint.
ABSTRACT
Objective: The similarities and the differences among Peru's Ginseng healthcare product, Radix Ginseng and Panax quinquefolium were studied. Methods: The work was performed by analysis of HPLC FPS and 4 dimensional UV FPS. Results: Their 4 dimensional UV FPS were very similar with each other, and the common peaks ratio of the components extracted from Peru's Ginseng healthcare product, Radix Ginseng with absolute alcohol was larger than that of the components extracted from Peru's Ginseng healthcare product and Panax quinquefolium. The variant ratio between the healthcare product and Radix Ginseng were more similar and much lower than that between the healthcare product and Panax quinquefolium. Conclusion: The components extracted from the healthcare product with absolute alcohol are the same as that from Radix Ginseng and are of quite large difference from the components from Panax quinquefolium.